Bisabolol

1. Bisabolol Overview

Bisabolol, also known as α-bisabolol or levomenol, is a monoterpene compound and the most widely used soothing and repairing active ingredient in the cosmetics industry. Currently, there are three primary production methods: biological fermentation, natural plant extraction, and chemical synthesis. Plamed dopts a natural fermentation approach, utilizing advanced microbial fermentation technology to produce (-)-α-Bisabolol identical to its natural plant counterpart. This cosmetic-grade product boasts a purity ≥98% and strictly controlled allergen levels ≤0.05%, offering high activity, thermal stability, and green sustainability. The core biological activities of bisabolol include: blocking classic inflammatory signaling pathways (NF-κB and MAPK), downregulating pro-inflammatory factor release to reduce inflammatory responses; simultaneously enhancing skin barrier function and promoting self-repair of damaged tissues. It also exhibits broad-spectrum antibacterial and antioxidant properties. Thus, it delivers anti-inflammatory soothing, barrier repair, antibacterial acne control, and auxiliary brightening/antioxidant skincare benefits. Cosmetics incorporating this ingredient alleviate sensitive skin concerns like redness, stinging, dryness, and itching, accelerate damaged barrier repair, and improve acne inflammation. suiting the needs of sensitive skin, post-medical aesthetic procedures, and acne-prone complexions. It is widely incorporated into soothing repair, acne treatment, post-sun care, and anti-sensitivity stabilizing cosmetics.

Product Name	CAS Number	INCI Name
Bisabolol	23089-26-1	BISABOLOL
Molecular Weight	Molecular Formula	Molecular Structure
C15H26O	222.37g/mol
Product ID	Specification	Minimal Package	MOQ
PMM3401	Purity≥98.0%	1KG	1KG

2. Bisabolol Source

Cosmetic-grade bisabolol is produced through biofermentation, natural plant extraction, and chemical synthesis. Plamed employs biofermentation technology to achieve large-scale production of high-purity (-)-α-bisabolol. This approach eliminates supply chain risks associated with seasonal and geographical constraints of plant extraction while avoiding the use of organic solvents in chemical synthesis. It represents an ideal choice that balances green sustainability with exceptional efficacy.

3. Bisabolol Manufacturer Specifications

4. Bisabolol Manufacturer Flow Chart

5. Bisabolol Benefits

• Anti-inflammatory and soothing

Beta-sitosterol can block the NF-κB and MAPK classical inflammatory signaling pathways, dose-dependently downregulating the transcription and release of pro-inflammatory factors IL-1β, IL-6, TNF-α, and leukotriene B4. Simultaneously, it interrupts the skin inflammation cascade, rapidly alleviating sensitivity discomforts such as redness, stinging, itching, and edema caused by external irritants or barrier damage. Studies demonstrate that L-alpha-bisabolol provides effective soothing for both allergic skin and pediatric skin, with significantly superior efficacy compared to synthetic racemic mixtures. Consequently, bisabolol rapidly alleviates skin sensitivity and discomfort while inhibiting inflammatory responses, establishing it as a core active ingredient for sensitive skin care.

• Barrier Repair

Beta-sitosterol promotes proliferation and differentiation of human keratinocytes, upregulates the gene and protein expression of filaggrin, loricrin, and occludin—the three core structural proteins of the skin barrier. It strengthens the stratum corneum, reduces transepidermal water loss (TEWL), accelerates the regeneration and repair of damaged skin barriers, and fundamentally enhances the skin’s moisture retention capacity and resistance to external irritants. Therefore, Bisabolol effectively repairs compromised skin barriers, fortifies the skin foundation, and reduces the likelihood of recurrent redness and sensitivity in sensitive skin.

• Antibacterial and anti-acne

Beta-sitosterol exhibits broad-spectrum antibacterial activity while suppressing inflammatory reactions at acne lesions. It reduces inflammation and swelling in red, inflamed pimples, accelerates their resolution, and minimizes post-acne marks. Unlike antibiotics, it carries no risk of developing resistance and is gentle on acne-prone skin without compromising the skin barrier. Therefore, Bisabolol gently improves inflammatory acne, regulates the skin microbiome, and meets the acne-fighting and repair needs of oily and acne-prone skin.

• Auxiliary whitening and antioxidant

Bisabolol scavenges DPPH radicals, hydroxyl radicals, and superoxide anions, inhibits lipid peroxidation, and reduces damage to skin caused by UV-induced reactive oxygen species (ROS). It also inhibits tyrosinase activity to reduce melanin production and alleviates skin irritation caused by whitening ingredients (such as retinol, niacinamide, and acids), enhancing the gentleness and tolerability of whitening products.

6. Bisabolol Advantages

• Optimal safety profile with strict control of the allergen acacia alcohol (≤0.05%);
• High purity (≥98.0%) and high active ingredient content (≥95.0%), delivering efficacy far exceeding industry standards.

7. Bisabolol Application and Reference Dosage

• Bisabolol possesses excellent lipophilicity and transdermal absorption capabilities, delivering significant efficacy even at low concentrations. It’s widely used in sensitive skin repair serums/creams, post-sun care products, medical aesthetic post-procedure repair products, acne gels/ serums, soothing systems for potent treatment products, infant skincare products, and sunscreen formulations. It serves as a core foundational ingredient for soothing and repairing in cosmetics.

Notes:

• Bisabolol is a lipophilic ingredient that is poorly soluble in water. During formulation preparation, it must first be dissolved in the oil phase before being incorporated into the formula.
• Bisabolol exhibits excellent stability to light and heat. Conventional cosmetic manufacturing processes cause no loss of activity. For long-term storage, it is recommended to keep the product away from light, sealed, and stored at room temperature.

Bisabolol application cases in major cosmetic brands in the world:

8. Bisabolol Safety

• Bisabolol has been included in China’s Catalogue of Cosmetic Ingredients in Use (2021 Edition).
• The U.S. Personal Care Products Council (PCPC, formerly CTFA) and the European Union Cosmetic Ingredient Notification Portal (CPNP) both list bisabolol as a compliant cosmetic ingredient.
• The Japan Cosmetic Industry Association (JCIA) and the Ministry of Food and Drug Safety (MFDS) of South Korea list bisabolol as a compliant soothing and repairing ingredient in their respective ingredient directories.
• The European Scientific Committee on Consumer Safety (SCCS) has affirmed its safety for use in cosmetics.
• Repeated skin irritation tests, sensitization tests, and human clinical trials confirm that bisabolol exhibits high topical safety with no irritation, phototoxicity, or sensitization potential.

9. Package and Storage

Package: 1kg/bag, 25 bags packed in cardboard drums lined with double-layer plastic bags.
Storage: Store in a dry, well-ventilated area away from direct sunlight and high temperatures. and oxidizing agents.

Plamed focuses on natural cosmetic ingredients for more than 10 years. We have founded four subsidiary companies, which respectively develops different kinds of cosmetic raw material. Plamed is a company whose CEO is designated as the first secretary general of Shaanxi Plant Extraction Association.

As a professional Bisabolol manufacturer, Plamed have been constantly upgrading the production process. We firmly believe that good Bisabolol and good Bisabolol price will help customers make good terminal products and help customers win a lasting and broad market.