Acetyl Hexapeptide-8 Manufacturer

2. Acetyl Hexapeptide-8 Source

Acetyl Hexapeptide-8 is prepared through chemical synthesis, which primarily encompasses two methods: solid-phase peptide synthesis (SPPS) and liquid-phase peptide synthesis (LPPS). Plamed employs solid-phase peptide synthesis (SPPS) technology to provide customers with raw materials characterized by high purity, consistent batch stability, and suitability for large-scale production.

3. Acetyl Hexapeptide-8 Manufacturer Specifications

4. Acetyl Hexapeptide-8 Manufacturer Flow Chart

5. Acetyl Hexapeptide-8 Benefits

• Anti-wrinkle

Acetyl Hexapeptide-8, as a botulinum toxin-like active peptide, competitively binds to the SNAP-25 protein on the presynaptic membrane. Then it blocks the fusion of synaptic vesicles with the cell membrane, inhibiting the release of acetylcholine. Consequently, it reduces excessive contraction of facial muscles, thereby diminishing dynamic expression lines such as forehead wrinkles, crow’s feet, and glabellar lines at their source. Plamed’s test has proved that at a concentration of 0.002%, Acetyl Hexapeptide-8 exhibits significant inhibition of acetylcholine content, with an inhibition rate of 20.58%. It simultaneously suppresses catecholamine release, reduces muscle contraction frequency, and delays the formation of new expression lines.

• Improve static fine lines, firming and anti-aging

Acetyl Hexapeptide-8 promotes the proliferation and differentiation of skin fibroblasts, upregulating the gene expression of Type I collagen, Type III collagen, and elastin. Research confirms this ingredient reverses UV-induced photoaging-related collagen loss in fibroblasts in a dose-dependent manner. It enhances dermal extracellular matrix synthesis, increases dermal thickness, improves skin laxity and dryness, fills static wrinkle depressions, and restores skin firmness and elasticity.

• Soothing and repair, gentle and non-irritating

Acetyl Hexapeptide-8 inhibits the release of inflammatory factors IL-6 and TNF-α, reducing skin inflammatory responses and alleviating redness and sensitivity caused by external irritants. Studies indicate that in LPS-induced macrophage inflammation models, Acetyl Hexapeptide-8 achieved maximum inhibition rates of 42.3% and 38.7% for inflammatory factors at concentrations of 0.01–0.1 mmol/L. It also promotes keratinocyte proliferation, accelerates stratum corneum barrier repair, and enhances skin moisture retention and resilience. As a small-molecule peptide, it exhibits excellent skin compatibility. The high-purity product, manufactured via SPPS technology, is free from irritating impurities, making it suitable for anti-aging needs in sensitive skin.

6. Acetyl Hexapeptide-8 Advantages

• High purity (≥99%) and high peptide content (≥85.0%), stable quality control;
• Strong batch consistency, suitable for large-scale supply;
• Excellent water solubility, broad formulation compatibility;
• Free from animal-derived ingredients, aligning with green skincare principles.

7. Acetyl Hexapeptide-8 Application and Reference Dosage

Acetyl Hexapeptide-8 exhibits exceptional transdermal absorption capabilities, delivering noticeable wrinkle-reducing and firming effects even at low concentrations. Widely formulated into anti-aging serums, wrinkle-fighting creams, firming lotions, eye serums/creams, neck creams, and masks, it stands as a core active ingredient in premium anti-aging skincare products.

It synergistically enhances the efficacy of ingredients like sodium hyaluronate, collagen, and Hydroxypropyl Tetrahydropyrantriol, delivering comprehensive anti-aging benefits.

Notes:

• Acetyl Hexapeptide-8 exhibits optimal stability in systems with pH0-7.0. It is not recommended for use with strong acids, strong bases, strong oxidizing agents, acyl chlorides, or acid anhydrides.
• Acetyl Hexapeptide-8 is sensitive to high temperatures; it is recommended to add it last in the formulation system at temperatures below 45°C.
• Acetyl Hexapeptide-8 oxidizes readily upon exposure to light and should be stored sealed at 2-8°C.

Acetyl Hexapeptide-8 application cases in major cosmetic brands in the world:

8. Acetyl Hexapeptide-8 Safety

• Acetyl Hexapeptide-8 has been included in the CFDA’s “List of Cosmetic Ingredients in Use (2021 Edition).”
• Both the Personal Care Products Council (PCPC, formerly CTFA) in the United States and the European Union’s Cosmetic Ingredient Notification Portal (CPNP) list Acetyl Hexapeptide-8 as a compliant cosmetic ingredient.
• The Japan Cosmetic Industry Association (JCIA) and the Ministry of Food and Drug Safety (MFDS) of South Korea list Acetyl Hexapeptide-8 as a compliant anti-aging ingredient in their respective ingredient directories. It is a mainstream peptide ingredient used by cosmetic brands in Japan, South Korea, and the United States.
• Multiple in vitro and in vivotrials confirm that acetyl hexapeptide-8 exhibits no skin irritation, eye irritation, sensitization, or phototoxicity when applied topically. At normal usage concentrations, it demonstrates no toxic side effects, and no reports of topical safety concerns have been documented since its market introduction.

9. Acetyl Hexapeptide-8 Package and Storage

Package: 10g bottle packaging, with a sterile aluminum foil seal inside the bottle mouth.

Storage: Store in cool and dry place at temperature 2 to 8℃, keep away from strong light.
Use it as soon as possible after unpacking.

Plamed focuses on natural cosmetic ingredients for more than 10 years. We have founded four subsidiary companies, which respectively develops different kinds of cosmetic raw material. Plamed is a company whose CEO is designated as the first secretary general of Shaanxi Plant Extraction Association.

As a professional Acetyl Hexapeptide-8 manufacturer, Plamed have been constantly upgrading the production process. We firmly believe that good Acetyl Hexapeptide-8 and good Acetyl Hexapeptide-8 price will help customers make good terminal products and help customers win a lasting and broad market.